A study (I saw it mentioned in "SELF MAGAZINE"), I believe at one of the universities found that people on anti depressants had a significantly lower percentage of heart attacks than those not on anti depressants. The study was financed by the manufacturer of Zoloft, using their product ...at the time it was thought that the benefits of the reduction of stress which may happen with an antidepressant far outweighed any side effects of the drug.
However, recent studies have found that the SSRI antidepressant medications including Zoloft increase the risk of heart attack and at present there are some class action lawsuits going against the pharmaceutical companies producing these drugs. In "PROZAC BACKLASH", Dr Joseph Glenmullen, MD pointed out that the SSRI medications also upset brain chemicals by causing a flood of serotonin which cause the body to overproduce dopamine raising the risk for Parkinson's Disease. Remember, we are not depressed due to a lack of Zoloft or other SSRI medications!
That being said, liver failure has increased significantly in 20th and 21th century.